Therapeutic cancer vaccines: From initial findings to prospects
With the approval of the first therapeutic cancer vaccine by US Food and Drug
Administration, numerous therapeutic cancer vaccines have been under clinical trials with …
Administration, numerous therapeutic cancer vaccines have been under clinical trials with …
2011: the immune hallmarks of cancer
Ten years after the publication of the position paper “The hallmarks of cancer”(Hanahan and
Weinberg Cell 100: 57–70, 2000), it has become increasingly clear that mutated cells on …
Weinberg Cell 100: 57–70, 2000), it has become increasingly clear that mutated cells on …
Genetic cancer vaccines: current status and perspectives
L Aurisicchio, G Ciliberto - Expert opinion on biological therapy, 2012 - Taylor & Francis
Introduction: The recent approval of the first therapeutic cancer vaccine by the US
Regulatory Agency represents a breakthrough event in the history of cancer treatment. The …
Regulatory Agency represents a breakthrough event in the history of cancer treatment. The …
Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene …
DNA vaccines are an attractive approach to eliciting antigen-specific immunity. Intracellular
targeting of tumor antigens through its linkage to immunostimulatory molecules such as …
targeting of tumor antigens through its linkage to immunostimulatory molecules such as …
Phase 1 studies of the safety and immunogenicity of electroporated HER2/CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors
CM Diaz, A Chiappori, L Aurisicchio, A Bagchi… - Journal of translational …, 2013 - Springer
Background DNA electroporation has been demonstrated in preclinical models to be a
promising strategy to improve cancer immunity, especially when combined with other …
promising strategy to improve cancer immunity, especially when combined with other …
Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach
PS Kim, PP Lee - PLoS computational biology, 2012 - journals.plos.org
A next generation approach to cancer envisions developing preventative vaccinations to
stimulate a person's immune cells, particularly cytotoxic T lymphocytes (CTLs), to eliminate …
stimulate a person's immune cells, particularly cytotoxic T lymphocytes (CTLs), to eliminate …
Telomerase and HER-2/neu as targets of genetic cancer vaccines in dogs
D Peruzzi, G Mesiti, G Ciliberto, N La Monica… - Vaccine, 2010 - Elsevier
Pet dogs represent a valuable pre-clinical model to assess the efficacy of oncology drugs.
Additionally, canine cancers occur with an incidence similar to that of humans and share …
Additionally, canine cancers occur with an incidence similar to that of humans and share …
Breast cancer cell CD200 expression regulates immune response to EMT6 tumor cells in mice
RM Gorczynski, Z Chen, J Diao, I Khatri… - Breast cancer research …, 2010 - Springer
CD200 has been characterized as an important immunoregulatory molecule, increased
expression of which can lead to decreased transplant rejection, autoimmunity, and allergic …
expression of which can lead to decreased transplant rejection, autoimmunity, and allergic …
HER-2/neu as a target for cancer vaccines
CN Baxevanis, IF Voutsas, AD Gritzapis, SA Perez… - …, 2010 - Taylor & Francis
A novel modality toward the treatment of HER-2/neu-positive malignancies, mostly including
breast and, more recently prostate carcinomas, has been the use of vaccines targeting HER …
breast and, more recently prostate carcinomas, has been the use of vaccines targeting HER …
Novel metronomic chemotherapy and cancer vaccine combinatorial strategy for hepatocellular carcinoma in a mouse model
M Tagliamonte, A Petrizzo, M Napolitano… - Cancer Immunology …, 2015 - Springer
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and represents
the third and the fifth leading cause of cancer-related death worldwide in men and women …
the third and the fifth leading cause of cancer-related death worldwide in men and women …