Systemic inflammation after stroke: implications for post‐stroke comorbidities

A Simats, A Liesz - EMBO molecular medicine, 2022 - embopress.org
Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022 - Am Heart Assoc
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Monocytes re-enter the bone marrow during fasting and alter the host response to infection

H Janssen, F Kahles, D Liu, J Downey, LL Koekkoek… - Immunity, 2023 - cell.com
Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via
its influence on immunity and metabolism, caloric restriction and fasting appear to be …

Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury: JACC State-of-the-Art Review

LA Sposato, MJ Hilz, S Aspberg, SB Murthy… - Journal of the american …, 2020 - jacc.org
Over 1.5 million deaths worldwide are caused by neurocardiogenic syndromes.
Furthermore, the consequences of deleterious brain-heart interactions are not limited to fatal …

Immunodepression, infections, and functional outcome in ischemic stroke

WF Westendorp, C Dames, PJ Nederkoorn, A Meisel - Stroke, 2022 - Am Heart Assoc
Stroke remains one of the main causes of mortality and morbidity worldwide. Immediately
after stroke, a neuroinflammatory process starts in the brain, triggering a systemic …

Hematopoiesis and cardiovascular disease

WC Poller, M Nahrendorf, FK Swirski - Circulation research, 2020 - Am Heart Assoc
A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

Modifiable cardiovascular risk, hematopoiesis, and innate immunity

MJ Schloss, FK Swirski, M Nahrendorf - Circulation research, 2020 - Am Heart Assoc
Unhealthy diet, lack of exercise, psychosocial stress, and insufficient sleep are increasingly
prevalent modifiable risk factors for cardiovascular disease. Accumulating evidence …

Bone marrow activation in response to metabolic syndrome and early atherosclerosis

A Devesa, M Lobo-González… - European heart …, 2022 - academic.oup.com
Aims Experimental studies suggest that increased bone marrow (BM) activity is involved in
the association between cardiovascular risk factors and inflammation in atherosclerosis …

Effects of lifestyle factors on leukocytes in cardiovascular health and disease

H Janssen, LL Koekkoek, FK Swirski - Nature Reviews Cardiology, 2024 - nature.com
Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence
the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have …

Bone marrow-derived naïve B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozin

Y Xu, K Jiang, F Chen, J Qian, D Wang, Y Wu… - Basic Research in …, 2022 - Springer
The role of adaptive immunity in myocardial recovery post myocardial infarction (MI),
particularly the immune response by B lymphocytes, remains elusive. Bone marrow immune …