In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …

Neuropeptide Y (NPY) exerts a powerful orexigenic effect in the hypothalamus. However,
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …

The neuropeptide hypocretin/orexin plays a broad and important role in physiological
functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and …

Reducing sleep hours is a risk factor for developing cardiovascular, metabolic, and
psychiatric disorders. Furthermore, previous studies have shown that reduction in sleep time …

Abstract An estimated 50–90% of individuals with cocaine use disorder (CUD) also report
using alcohol. Cocaine users report coabusing alcohol to 'self-medicate'against the negative …

Learning and memory disorders and decreased neuroplasticity are the main clinical
manifestations of age‐induced cognitive dysfunction. Orexin A (OxA) has been reported to …

The orexin (hypocretin) system is multifaceted, and regulates sleep-wake cycles,
nociception, endocrine function and reward-seeking behavior. We have established an …