[HTML][HTML] Invited review: The influence of immune activation on transition cow health and performance—A critical evaluation of traditional dogmas

EA Horst, SK Kvidera, LH Baumgard - Journal of Dairy Science, 2021 - Elsevier
The progression from gestation into lactation represents the transition period, and it is
accompanied by marked physiological, metabolic, and inflammatory adjustments. The entire …

Acute phase proteins in ruminants

F Ceciliani, JJ Ceron, PD Eckersall, H Sauerwein - Journal of proteomics, 2012 - Elsevier
The physiological response to infections and injuries involves local inflammation and the
initiation of events leading to a systemic response, also called acute phase reaction (APR) …

Tolerance and innate immunity shape the development of postpartum uterine disease and the impact of endometritis in dairy cattle

IM Sheldon, JG Cronin… - Annual review of animal …, 2019 - annualreviews.org
Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows
tolerated these bacteria and few animals developed uterine disease. Now, up to 40% of …

Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle

IM Sheldon, J Cronin, L Goetze, G Donofrio… - Biology of …, 2009 - academic.oup.com
Uterine microbial disease affects half of all dairy cattle after parturition, causing infertility by
disrupting uterine and ovarian function. Infection with Escherichia coli, Arcanobacterium …

β-Defensins: farming the microbiome for homeostasis and health

KG Meade, C O'Farrelly - Frontiers in Immunology, 2019 - frontiersin.org
Diverse commensal populations are now regarded as key to physiological homeostasis and
protection against disease. Although bacteria are the most abundant component of …

Postpartum uterine infection and endometritis in dairy cattle

IM Sheldon, SE Owens - Animal Reproduction (AR), 2018 - animal-reproduction.org
After parturition, uterine involution, regeneration of the endometrium, return of ovarian cyclic
activity, and the control of pathogenic bacteria in the uterus is required before cows are likely …

Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle

IM Sheldon, SB Price, J Cronin… - … in domestic animals, 2009 - Wiley Online Library
Contents Clinical and subclinical endometritis are common causes of infertility and
subfertility in high producing dairy cattle, delaying the onset of ovarian cyclic activity after …

Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria

IM Sheldon, PCC Molinari, TJR Ormsby, JJ Bromfield - Theriogenology, 2020 - Elsevier
Up to forty percent of dairy cows develop metritis or endometritis when pathogenic bacteria
infect the uterus after parturition. However, resilient cows remain healthy even when …

Innate immunity and inflammation of the bovine female reproductive tract in health and disease

IM Sheldon, JG Cronin, GD Healey, C Gabler… - …, 2014 - rep.bioscientifica.com
In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …

Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like …

ML Turner, JG Cronin, GD Healey, IM Sheldon - Endocrinology, 2014 - academic.oup.com
Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease, and
infertility. Lipopeptides are commonly found among bacteria and are detected by the Toll …