Inflammation-induced DNA damage, mutations and cancer
The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …
connection linking inflammation to cancer development is DNA damage. During …
Replication stress and cancer
Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer
NL Burdett, MO Willis, K Alsop, AL Hunt, A Pandey… - Nature …, 2023 - nature.com
High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous
recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to …
recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to …
Therapeutic opportunities within the DNA damage response
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …
Targeted and persistent 8-oxoguanine base damage at telomeres promotes telomere loss and crisis
Telomeres are essential for genome stability. Oxidative stress caused by excess reactive
oxygen species (ROS) accelerates telomere shortening. Although telomeres are …
oxygen species (ROS) accelerates telomere shortening. Although telomeres are …
Arginine methylation of the DDX 5 helicase RGG/RG motif by PRMT 5 regulates resolution of RNA: DNA hybrids
Aberrant transcription‐associated RNA: DNA hybrid (R‐loop) formation often causes
catastrophic conflicts during replication, resulting in DNA double‐strand breaks and …
catastrophic conflicts during replication, resulting in DNA double‐strand breaks and …
Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
O Kiraly, G Gong, W Olipitz, S Muthupalani… - PLoS …, 2015 - journals.plos.org
Mutations are a critical driver of cancer initiation. While extensive studies have focused on
exposure-induced mutations, few studies have explored the importance of tissue physiology …
exposure-induced mutations, few studies have explored the importance of tissue physiology …
Opportunities and challenges with CRISPR-Cas mediated homologous recombination based precise editing in plants and animals
Key message We summarise recent advancements to achieve higher homologous
recombination based gene targeting efficiency in different animals and plants. Abstract The …
recombination based gene targeting efficiency in different animals and plants. Abstract The …
Proteomic profiling reveals a specific role for translesion DNA polymerase η in the alternative lengthening of telomeres
L Garcia-Exposito, E Bournique, V Bergoglio, A Bose… - Cell reports, 2016 - cell.com
Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres
(ALT) pathways for telomere maintenance and survival. ALT involves homologous …
(ALT) pathways for telomere maintenance and survival. ALT involves homologous …