Since the first discovery of antipsychotics in the 1950s, targeting dopaminergic drugs has
manifested to well manage the positive symptoms of schizophrenia with limited efficacy for …

Trace amines, a group of amines expressed at the nanomolar level in the mammalian brain,
can modulate monoamine transmission. The discovery of and the functional research on the …

Artificial intelligence is revolutionizing protein structure prediction, providing unprecedented
opportunities for drug design. To assess the potential impact on ligand discovery, we …

How the olfactory system detects and distinguishes odorants with diverse physicochemical
properties and molecular configurations remains poorly understood. Vertebrate animals …

The existing available antipsychotics have failed to manage the cognitive impairment of
schizophrenia and induced a number of seriously undesirable effects. Trace amine …

The trace-amine associated receptor-1 (TAAR1) is a member of the G-protein coupled
receptor (GPCR) receptor family and is widely distributed across the brain and …

Increasing global concerns about psychoactive substance addiction and psychotic disorders
highlight the need for comprehensive research into the structure-function relationship …

Large language models direct automated chemistry laboratory Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Delta opioid receptor (δOR) plays a pivotal role in modulating human sensation and
emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is …

Abstract Background Metabolic syndrome (MetS), which can be induced or exacerbated by
the current class of antipsychotic drugs, is highly prevalent in patients with schizophrenia …