Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Microtubules (composed of α-and β-tubulin heterodimers) play a pivotal role in mitosis and
cell division, and are regarded as an excellent target for chemotherapeutic agents to treat …

Microtubules are dynamic assemblies of αβ‐tubulin heterodimers and have been
recognized as highly attractive targets for cancer chemotherapy. A broad range of agents …

In this review, an attempt has been made to throw light on the mechanism of action of
colchicine and its different analogs as anti‐cancer agents. Colchicine interacts with tubulin …

Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …

Microtubules are protein biopolymers formed through polymerization of heterodimers of α-
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …

Discovering of new anticancer agents with potential activity against tubulin polymerisation is
still a promising approach. Colchicine binding site inhibitors are the most relevant anti …

Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural
molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its …

Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …