Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly
2 decades ago through the identification of rare subpopulations of engrafting cells in …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

We define the chromatin accessibility and transcriptional landscapes in 13 human primary
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …

Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …

An emerging concept in the field of cancer biology is that a rare population of 'tumour stem
cells' exists among the heterogeneous group of cells that constitute a tumour. This concept …

The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …

▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …

Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in
AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-xL and …

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are
poorly understood. We determined global gene expression profiles for mouse and human …

Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …