Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

The production of large amounts of synthetic industrial and biomedical compounds, together
with environmental pollutants, poses a risk to our ecosystem and induces negative effects on …

The glucocorticoid receptor (GR) is a bona fide ligand‐regulated transcription factor. Cloned
in the 80s, the GR has become one of the best‐studied and clinically most relevant members …

1. Introduction 2. Molecular Regulation of the Hypothalamic–Pituitary–Interrenal (HPI) Axis
2.1. Hypothalamus 2.2. Pituitary 2.3. Head Kidney (Interrenal Tissue) 3. Genomic Cortisol …

The activating molecule in Beclin-1-regulated autophagy (Ambra1), also known as
autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and vertebrate-conserved …

Glucocorticoids (GCs) play important roles in developmental and physiological processes
through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 …

The zebrafish (Danio rerio) has emerged as a model species for translational research in
various neuroscience areas, including depressive disorders. Because of their physiological …

Environmental toxicology has been expanding as growing concerns on the impact of
produced and released chemical compounds over the environment and human health are …

Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue
homeostasis and regulate the cellular response to stress and inflammation, highlighting the …