On-demand therapeutic delivery of hydrogen sulfide aided by biomolecules

Y Ge, F Rong, W Li, Y Wang - Journal of Controlled Release, 2022 - Elsevier
Abstract Hydrogen sulfide (H 2 S), known as the third gasotransmitter, exerts various
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …

Nanocarriers for the delivery of neuroprotective agents in the treatment of ocular neurodegenerative diseases

C Patel, S Pande, V Sagathia, K Ranch, J Beladiya… - Pharmaceutics, 2023 - mdpi.com
Retinal neurodegeneration is considered an early event in the pathogenesis of several
ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and …

External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release

X Ji, Z Zhong - Journal of Controlled Release, 2022 - Elsevier
Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …

Pharmaceutical approaches to Normal tension Glaucoma

ML Salvetat, F Pellegrini, L Spadea, C Salati… - Pharmaceuticals, 2023 - mdpi.com
Normal tension glaucoma (NTG) is defined as a subtype of primary open-angle glaucoma
(POAG) in which the intraocular pressure (IOP) values are constantly within the statistically …

Co-delivery of Brinzolamide and Timolol from Micelles-laden Contact Lenses: In vitro and In Vivo Evaluation

H Yang, F Zhang, Y Fan, J Zhang, T Fang… - Pharmaceutical …, 2024 - Springer
Purpose Traditional eye drops exhibit a modest bioavailability ranging from 1 to 5%,
necessitating recurrent application. Thus, a contact lens-based drug delivery system …

Polyzwitterionic Nanogels for the Controlled and Sustained Delivery of NO and H2S

U Bairagi, SK Rainu, N Singh… - ACS Applied Nano …, 2023 - ACS Publications
Nanomaterials capable of the controlled and sustained release of nitric oxide (NO) and
hydrogen sulfide (H2S) have broad therapeutic implications. In this research work, we report …

A fluorescent probe for detecting H2O2 and delivering H2S in lysosomes and its application in maintaining the redox environments

C Xu, Y Zhang, M Ren, K Liu, Q Wu, C Zhang, S Wang… - Talanta, 2024 - Elsevier
Abstract Hydrogen peroxide (H 2 O 2) is a reactive oxygen species (ROS) that can be used
as a marker for the occurrence of oxidative stress in the organism. Lysosomes serve as …

NO-and H2S-releasing nanomaterials: A crosstalk signaling pathway in cancer

RA Dos Reis, I Sarkar, MG Rodrigues, JB Matson… - Nitric Oxide, 2024 - Elsevier
The gasotransmitters nitric oxide (NO) and hydrogen sulfide (H 2 S) play important roles not
only in maintaining physiological functions, but also in pathological conditions and events …

Self-management challenges and support needs among patients with primary glaucoma: a qualitative study

Y Hua, H Lu, J Dai, Y Zhou, W Zhou, A Wang, Y Chen… - BMC nursing, 2023 - Springer
Background Self-management plays an important role in the disease management of
glaucoma patients. The effectiveness of the program can be improved by assessing the …

Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors

R Sparaco, V Citi, E Magli, A Martelli… - International Journal of …, 2022 - mdpi.com
Glaucoma is a group of eye diseases consisting of optic nerve damage with corresponding
loss of field vision and blindness. Hydrogen sulfide (H2S) is a gaseous neurotransmitter …