The emergence and evolution of SARS-CoV-2
EC Holmes - Annual review of virology, 2024 - annualreviews.org
The origin of SARS-CoV-2 has evoked heated debate and strong accusations, yet
seemingly little resolution. I review the scientific evidence on the origin of SARS-CoV-2 and …
seemingly little resolution. I review the scientific evidence on the origin of SARS-CoV-2 and …
Molecular determinants of cross-species transmission in emerging viral infections
A Wickenhagen, S van Tol… - … and Molecular Biology …, 2024 - journals.asm.org
Several examples of high-impact cross-species transmission of newly emerging or re-
emerging bat-borne viruses, such as Sudan virus, Nipah virus, and severe acute respiratory …
emerging bat-borne viruses, such as Sudan virus, Nipah virus, and severe acute respiratory …
Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice
The emergence of three highly pathogenic human coronaviruses—severe acute respiratory
syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern respiratory syndrome (MERS) …
syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern respiratory syndrome (MERS) …
[HTML][HTML] Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
A Schäfer, LE Gralinski, SR Leist, BK Hampton… - Virus Research, 2024 - Elsevier
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other
mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in …
mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in …
Will releasing the weights of large language models grant widespread access to pandemic agents?
A Gopal, N Helm-Burger, L Justen, EH Soice… - arXiv preprint arXiv …, 2023 - arxiv.org
Large language models can benefit research and human understanding by providing
tutorials that draw on expertise from many different fields. A properly safeguarded model will …
tutorials that draw on expertise from many different fields. A properly safeguarded model will …
Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination
We used plasma IgG proteomics to study the molecular composition and temporal durability
of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or …
of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or …
A system capable of verifiably and privately screening global DNA synthesis
Printing custom DNA sequences is essential to scientific and biomedical research, but the
technology can be used to manufacture plagues as well as cures. Just as ink printers …
technology can be used to manufacture plagues as well as cures. Just as ink printers …
[HTML][HTML] Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates
Immunization with mRNA or viral vectors encoding spike with diproline substitutions (S-2P)
has provided protective immunity against severe COVID-19 disease. How immunization with …
has provided protective immunity against severe COVID-19 disease. How immunization with …
[HTML][HTML] A Comparative Experimental and Computational Study on the Nature of the Pangolin-CoV and COVID-19 Omicron
The relationship between pangolin-CoV and SARS-CoV-2 has been a subject of debate.
Further evidence of a special relationship between the two viruses can be found by the fact …
Further evidence of a special relationship between the two viruses can be found by the fact …
Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic
preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) …
preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) …