Both chronic obstructive pulmonary disease (COPD) and lung cancer are major causes of
death worldwide. In most cases this reflects cigarette smoke exposure which is able to …

Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of
morbidity and mortality worldwide. They share a common environmental risk factor in …

Chronic obstructive pulmonary disease (COPD) and lung cancer currently form the basis for
an enormous disease burden in the developed world. As a result of changing smoking …

Exposure to cigarette smoke (CS) is the most common cause of emphysema, a debilitating
pulmonary disease histopathologically characterized by the irreversible destruction of lung …

Background Nuclear factor-κB (NF-κB) signaling plays essential roles in inflammatory
responses. However, whether the expression levels of NF-κB family genes affect …

Background There is a need for more powerful methods to identify low-effect SNPs that
contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to …

Cigarette smoke (CS) exposure is unquestionably the most frequent cause of emphysema in
the United States. Accelerated pulmonary endothelial cell (EC) apoptosis is an early …

Genome-wide association studies aim to correlate genotype with phenotype. Many common
diseases including Type II diabetes, Alzheimer's, Parkinson's and Chronic Obstructive …