Calcineurin is a eukaryotic Ca2+-and calmodulin-dependent serine/threonine protein
phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A …

Ca2+/calmodulin (CaM)-dependent protein kinase (CaMKII) is a ubiquitous mediator of
Ca2+-linked signalling that phosphorylates a wide range of substrates to co-ordinate and …

Specificity of protein kinases and phosphatases may be achieved through
compartmentalization with preferred substrates. In neurons, adenosine 3′, 5 …

Since its discovery a quarter century ago, the cAMP‐dependent protein kinase has been a
central model for study of the mode of transduction of second messenger signals; more than …

To elucidate the role cAMP-dependent protein kinase (PKA) phosphorylations on tau play in
Alzheimer's disease, we have generated highly specific monoclonal antibodies, CP-3 and …

The accessory structures (fibrous sheath and outer dense fibers) of the mouse sperm
flagellum are composed of a heterogeneous array of polypeptides, including a prominent …

The molecular basis of mammalian sperm capacitation, defined as those biochemical and
functional changes that render the sperm competent to fertilize the egg, is poorly …

We have previously identified receptors for activated C kinase (RACKs) as components of
protein kinase C (PKC) signaling. RACK1, a recently cloned 36-kDa RACK, has short …

U937 monocytic cells are shown here to express a range of PDE4, cAMP-specific
phosphodiesterase (PDE) isoenzymes: the long isoenzymes, PDE4A4, PDE4D5 and …

Kinase anchoring has gained acceptance as a means to synchronize spatial and temporal
aspects of cell signaling. A-kinase anchoring proteins (AKAPs) are a diverse group of …