Cardiovascular disease is a leading cause of death worldwide. The underlying mechanisms
of most cardiovascular disorders involve innate and adaptive immune responses, and …

Extracellular vesicles (EVs) are important mediators of intercellular communication within
the cardiovascular system, playing essential roles in physiological homeostasis and …

Abstract Background and Aims Valve interstitial cells (VICs) undergo a transition to
intermediate state cells before ultimately transforming into the osteogenic cell population …

Extracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major
public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) …

Objective We aim to analyse sex-specific differences in aortic valves (AVs) and valve
interstitial cells (VICs) from aortic stenosis (AS) patients. Approach and Results 238 patients …

Abstract Aims Homozygous familial hypercholesterolaemia (HoFH) is an orphan disease
defined by extreme elevations in low-density lipoprotein cholesterol, cutaneous xanthomas …

The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular
component of normal and pathological tissues of the embryo and adult. ECM acts as critical …

Background: Calcific aortic valve disease is common in the aging population and is
characterized by the histological changes of the aortic valves including extracellular matrix …

Background Calcific aortic valve disease (CAVD) is a common valve disease with an
increasing incidence, but no effective drugs as of yet. With the development of sequencing …

Aims Inflammatory cytokines play a critical role in the progression of calcific aortic valve
disease (CAVD), for which there is currently no pharmacological treatment. The aim of this …