Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …

Biguanides are a very interesting class of molecules which have been extensively studied
for their medicinal applications. The structural and electronic structural aspects of …

Cytochromes P450 are oxidizing enzymes; a few families of cytochromes P450 are
implicated in drug metabolism. These enzymatic reactions involve many processes …

Guanylthiourea (GTU) has been identified as an important antifolate antimalarial
pharmacophore unit, whereas, 4-amino quinolones are already known for antimalarial …

Atomoxetine (ATX), a selective and potent inhibitor of the presynaptic norepinephrine
transporter, is used mainly to treat attention-deficit hyperactivity disorder. Although multiple …

Drug metabolism of thiophene containing substrates by cytochrome P450s (CYP450) leads
to toxic side effects, for example, nephrotoxicity (suprofen, ticlopidine), hepatotoxicity (tienilic …

Introduction: Antimalarial drugs are the primary weapon to treat parasite infection, save lives,
and curtail further transmission. Accumulating data have indicated that at least some …

The dative‐bond representation (L→ E) in compounds with main group elements (E) has
triggered extensive debate in the recent past. The scope and limits of this nonclassical …

Azines belong to an important class of compounds that are found to have numerous
applications in medicinal chemistry. Hydrazones are related to azines and are more widely …