Age is the primary risk factor for many common human diseases. Here, we quantify the
relative contributions of genetics and aging to gene expression patterns across 27 tissues …

Accumulating evidence indicates that some protein-coding genes have originated de novo
from previously non-coding genomic sequences. However, the processes underlying de …

Gene regulatory divergence is thought to play a central role in determining human-specific
traits. However, our ability to link divergent regulation to divergent phenotypes is limited …

The formation of new genes during evolution is an important motor of functional innovation,
but the rate at which new genes originate and the likelihood that they persist over longer …

The human capacity to acquire sophisticated language is unmatched in the animal kingdom.
Despite the discontinuity in communicative abilities between humans and other primates …

Protein sequences are the result of an evolutionary process that involves the balancing act
of experimenting with novel mutations and selecting out those that have an undesirable …

Life history theory predicts that the intensity of selection declines with age, and this trend
should impact how genes expressed at different ages evolve. Here we find consistent …

There has been a large literature in the last two decades affirming adaptive DNA sequence
evolution between species. The main lines of evidence are from (i) the McDonald-Kreitman …

Many comparative genomics studies aim to find the genetic basis of species-specific
phenotypic traits. A prevailing strategy is to search genome-wide for genes that evolved …

The effect of a mutation on fitness may differ between populations depending on
environmental and genetic context, but little is known about the factors that underlie such …