Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of
them drive cancer progression, termed driver mutations. Driver mutations may vary between …

Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …

Most known pathogenic mutations occur in protein-coding regions of DNA and change the
way proteins are made. Taking protein structure into account has therefore provided great …

Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein
complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on …

Large-scale tumor sequencing projects enabled the identification of many new cancer gene
candidates through computational approaches. Here, we describe a general method to …

Highlights•Missense mutations frequently alter protein biophysical characteristics such as
stability, dynamics and interactions.•Protein biophysical properties are interrelated and …

Non-synonymous single nucleotide polymorphisms (nsSNPs) are single base changes
leading to a change to the amino acid sequence of the encoded protein. Many of these …

At the root of the so-called precision medicine or precision oncology, which is our focus
here, is the hypothesis that cancer treatment would be considerably better if therapies were …

Attempts at using protein structures to identify disease-causing mutations have been
dominated by the idea that most pathogenic mutations are disruptive at a structural level …

Statistical analysis was carried out on large set of naturally occurring human amino acid
variations, and it was demonstrated that there is a preference for some amino acid …