Cancer is the leading cause of mortality worldwide, accounting for almost 13% of deaths in
the world. Among the conventional cancer treatments, chemotherapy is most frequently …

Abstract Melatonin (N-acetyl-5-methoxy-tryptamine), which is generally considered as
pleiotropic and multitasking molecule, secretes from pineal gland at night under normal light …

Cachexia is among the most debilitating and life‐threatening aspects of cancer. Associated
with anorexia, fat and muscle tissue wasting, psychological distress, and a lower quality of …

Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting
in progressive weight loss. It is associated with poor quality of life, poor physical function …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine) is a molecule with a very wide
phylogenetic distribution from plants to man. In vertebrates, melatonin was initially thought to …

Cancer is a large group of diseases and the second leading cause of death worldwide.
Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer …

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness
of melatonin in different fields of medicine. The objective of this article is to review, in depth …

Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger,
an indirect antioxidant, as well as an important immunomodulatory agent. In both in vitro and …

Chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting neurotoxic effect of
chemotherapy, is the most common reason for early cessation of cancer treatment. This can …

Melatonin (MLT) has been proven to counteract chemotherapy toxicity, by acting as an anti-
oxidant agent, and to promote apoptosis of cancer cells, so enhancing chemotherapy …