More accurate and precise phenotyping strategies are necessary to empower high-
resolution linkage mapping and genome-wide association studies and for training genomic …

Inbreeding depression—the reduced survival and fertility of offspring of related individuals—
occurs in wild animal and plant populations as well as in humans, indicating that genetic …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Key message MAGIC populations present novel challenges and opportunities in crops due
to their complex pedigree structure. They offer great potential both for dissecting genomic …

Identifying natural allelic variation that underlies quantitative trait variation remains a
fundamental problem in genetics. Most studies have employed either simple synthetic …

Abstract The Collaborative Cross Consortium reports here on the development of a unique
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …

Most of the biological understanding of mechanisms underlying coronary artery disease
(CAD) derives from studies of mouse models. The identification of multiple CAD loci and …

The dissection of gene-trait associations and its translation into practice through plant
breeding is a central aspect of modern plant biology. The identification of genes underlying …

Linkage disequilibrium (LD) mapping in plants detects and locates quantitative trait loci
(QTL) by the strength of the correlation between a trait and a marker. It offers greater …

Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress
in the molecular dissection of complex traits in mice. Here we show that genome-wide high …