Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

To evaluate the clinical impact of molecular tumor profiling (MTP) with targeted sequencing
panel tests, pediatric patients with extracranial solid tumors were enrolled in a prospective …

With the increasing use of comprehensive germline genetic testing of children and
adolescents with cancer, it has become evident that pathogenic variants (PVs) in adult-onset …

Precision medicine has revolutionized clinical care for patients with cancer through the
development of targeted therapy, identification of inherited cancer predisposition syndromes …

Background Germline variant evaluation in precision oncology opens new paths toward the
identification of patients with genetic tumor risk syndromes and the exploration of therapeutic …

Pediatric cancer outcomes have significantly improved, and yet this success is not spread
equally across cancer types or patients. Disparities data in pediatric oncology highlight …

To inform clinical trial design and real-world precision pediatric oncology practice, we
classified diagnoses, assessed the landscape of mutations, and identified genomic variants …

PURPOSE To characterize parents' quality of life (QoL) after germline genomic sequencing
for their children with cancer. METHODS Participants were n= 104 parents of children with …

PURPOSE Guidelines recommend somatic and germline testing for men with advanced
prostate cancer (PCa). Barriers to widespread implementation result in underutilization of …

As germline genetic testing capacities have improved over the last two decades,
increasingly more people are newly diagnosed with germline cancer susceptibility …