Pharmacodynamic interactions of antiepileptic drugs: from bench to clinical practice

A Verrotti, S Lattanzi, F Brigo, G Zaccara - Epilepsy & Behavior, 2020 - Elsevier
Background Approximately 50% of patients do not achieve seizure control with antiepileptic
drug (AED) monotherapy, and polytherapy, with more than one AED, is often required. To …

Pharmacology of lacosamide: from its molecular mechanisms and pharmacokinetics to future therapeutic applications

A Carona, J Bicker, R Silva, C Fonseca, A Falcão… - Life Sciences, 2021 - Elsevier
Epilepsy is one of the most common brain disorders, affecting more than 50 million people
worldwide. Although its treatment is currently symptomatic, the last generation of anti-seizure …

Safety and tolerability of lacosamide in patients with epilepsy: a systematic review and meta-analysis

C Yang, Y Peng, L Zhang, L Zhao - Frontiers in pharmacology, 2021 - frontiersin.org
Background: As a third-generation antiseizure medication (ASM), lacosamide (LCM) is
recommended worldwide for patients with epilepsy. We aimed to provide more conclusive …

Applying policy process theories to environmental governance research: Themes and new directions

T Ruseva, M Foster, G Arnold, S Siddiki… - Policy Studies …, 2019 - Wiley Online Library
Policy scholars have effectively leveraged policy process models, theories, and frameworks
to respond to a variety of important environmental questions. For example, how do …

Lacosamide effectiveness and tolerability in patients with drug-resistant epilepsy and severe disability under polytherapy: Therapy optimization as emerging from an …

M Pozzi, N Zanotta, R Epifanio, S Baldelli… - Epilepsy & Behavior, 2022 - Elsevier
Objective We explored the efficacy and safety of lacosamide combined with inhibitors of fast-
inactivated sodium channels or with other antiepileptic drugs, in patients with drug refractory …

Efficacy upon 12-weeks after achievement of maximal dose and tolerability of lacosamide as an adjunctive therapy in epilepsy: Real world clinical experience

RS Chang, HKK Lui, HTC Lui, CYW Leung… - Journal of the …, 2020 - Elsevier
Lacosamide (LCM) is a new generation antiepileptic drug. It has only been available in Asia
in recent years. A retrospective study at two hospitals in Hong Kong was performed to …

New and emerging antiepileptic drugs

JM Witkin, LK Golani, JL Smith - Burger's Medicinal Chemistry …, 2003 - Wiley Online Library
This article provides the biologist, chemist, and clinician with an overview into currently
existing epilepsy medicines, an appreciation of those currently in development, and a …

Short-term Results of The Add-on Lacosamide Therapy in Patients with Drug-resistant Focal Onset Seizures

F Eren, AC Dirican, G Gül, B Tekin, D Atakli… - Archives of …, 2021 - search.proquest.com
INTRODUCTION: Lacosamide (LCM) is a new generation amino acid drug that is used in
patients with drug-resistant epilepsy, which increases the slow inactivation of voltage …

Rola tiagabiny w leczeniu padaczki–opis przypadków

P Bogucki - Medycyna Faktów, 2018 - journalsmededu.pl
Tiagabina jako terapia dodana może być skuteczna w wybranych przypadkach padaczki
ogniskowej, a jej połączenie z lakozamidem wydaje się efektywne u pacjentów, u których …