Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Skin undergoes constant self-renewal, and its functional decline is a visible consequence of
aging. Understanding human skin aging requires in-depth knowledge of the molecular and …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

The skin epidermis is constantly renewed throughout life,. Disruption of the balance between
renewal and differentiation can lead to uncontrolled growth and tumour initiation. However …

The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

In the skin, tissue injury results in fibrosis in the form of scars composed of dense
extracellular matrix deposited by fibroblasts. The therapeutic goal of regenerative wound …