Acyl coenzyme A binding protein (ACBP): An aging‐and disease‐relevant “autophagy checkpoint”

L Montégut, M Abdellatif, O Motiño, F Madeo… - Aging …, 2023 - Wiley Online Library
Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI),
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …

C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues

J Luo, C Bainbridge, RM Miller, A Barrios, DS Portman - Current Biology, 2024 - cell.com
For sexually reproducing animals, selecting optimal mates is important for maximizing
reproductive fitness. In the nematode C. elegans, populations reproduce largely by …

A Caenorhabditis elegans Male Pheromone Feminizes Germline Gene Expression in Hermaphrodites and Imposes Life-History Costs

D Angeles-Albores, EZ Aprison… - Molecular biology …, 2023 - academic.oup.com
Sex pheromones not only improve the reproductive success of the recipients, but also
impose costs, such as a reduced life span. The underlying mechanisms largely remain to be …

piRNAs regulate a Hedgehog germline-to-soma pro-aging signal

C Shi, CT Murphy - Nature Aging, 2023 - nature.com
The reproductive system regulates somatic aging through competing anti-and pro-aging
signals. Germline removal extends somatic lifespan through conserved pathways including …

An acyl-CoA thioesterase is essential for the biosynthesis of a key dauer pheromone in C. elegans

S Bhar, CS Yoon, K Mai, J Han, DV Prajapati… - Cell Chemical …, 2024 - cell.com
Methyl ketone (MK)-ascarosides represent essential components of several pheromones in
Caenorhabditis elegans, including the dauer pheromone, which triggers the stress-resistant …

Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila

GN Landis, HS Bell, O Peng, B Bognar, A Tong… - Plos one, 2023 - journals.plos.org
Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased
midgut size and decreased life span in female Drosophila. Feeding mated females with the …

Deadly males accelerate aging with piRNAs

EL Greer - Nature Aging, 2023 - nature.com
Mating is known to accelerate the aging of the opposite sex in a variety of species. A
transcriptomic analysis of extracted germlines from mated and unmated Caenorhabditis …