The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …

Background & Aims Exploiting key regulators responsible for hepatocarcinogenesis is of
great importance for the prevention and treatment of hepatocellular carcinoma (HCC) …

In our studies, cyclin B1 (CCNB1) mRNA and protein were overexpressed in hepatocellular
carcinoma (HCC) tissues compared with non-HCC tissues. Moreover, CCNB1 was …

Targeting protein quality control (PQC) pathways using proteasome or p97/VCP inhibition
can effectively treat blood tumors. However, in solid tumors, only p97/VCP inhibitors are …

The liver is a crucial center in the regulation of energy homeostasis under starvation.
Although downregulation of mammalian target of rapamycin complex 1 (mTORC1) has been …

Autophagy is a conserved cellular process, and its dysfunction is implicated in cancer and
other diseases. Here, we employ an in vivo CRISPR screen targeting genes implicated in …

Abstract The VCPIP1‐P97/VCP (Valosin‐Containing Protein) complex is required for post‐
mitotic Golgi cisternae reassembly and maintenance in interphase. However, the …

Background: Exosomes are essential for hepatocellular carcinoma (HCC) progression and
have garnered significant interest as novel targets for diagnostic, prognostic, and therapeutic …

Distinct functions mediated by members of the monopolar spindle-one-binder (MOB) family
of proteins remain elusive beyond the evolutionarily conserved and well-established roles of …

Two distinct p97ATPase-mediated membrane fusion pathways are required for Golgi and
endoplasmic reticulum (ER) biogenesis, namely, the p97/p47 pathway and the p97/p37 …