Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …

Background: Overweight and obesity in adults are common and adversely affect health.
Purpose: To summarize effectiveness and harms of primary care–relevant weight-loss …

Клинические рекомендации уже давно вошли в число рабочих инструментов
современного врача, помогая ему быстро ориентироваться в наиболее эффективных …

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from> 140,000 individuals of European ancestry within the …

The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials
with inconclusive results. Moreover, the effectiveness in a real-life outpatient setting has not …

Background: In response to the increase in obesity, pharmacologic treatments for weight
loss have become more numerous and more commonly used. Purpose: To assess the …

Background: Randomized trials of postmenopausal hormone therapy have found differing
effects on fasting glucose levels. No trial has evaluated the effect of hormone therapy on …

Background: Obesity poses a considerable and growing health burden. This review
examines evidence for screening and treating obesity in adults. Data Sources: MEDLINE …

Metformin, a biguanide, has been available in the US for the treatment of type 2 diabetes
mellitus for nearly 8 years. Over this period of time, it has become the most widely prescribed …

Managing obesity is a substantial aspect worldwide as well as in diabetic patients. Most oral
antidiabetic medications increase body weight. Metformin, the most recommended first-line …