Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Abstract Gamma-linolenic acid (GLA, 18: 3n-6) is an omega-6 (n-6), 18 carbon (18C-)
polyunsaturated fatty acid (PUFA) found in human milk and several botanical seed oils and …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from
phospholipase-released arachidonic acid that are involved in numerous homeostatic …

Aeroallergen sensing by airway epithelial cells triggers pathogenic immune responses
leading to type 2 inflammation, the hallmark of chronic airway diseases such as asthma. Tuft …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …

With the completion of genome sequences of major model organisms, increasingly
sophisticated genetic tools are necessary for investigating the complex and coordinated …

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic
inflammation and allergic diseases. They exert their biological effects by binding to specific …

Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as
mediators of allergic and inflammatory reactions and considered to be important drug …