Pathophysiology of sepsis-induced cardiomyopathy

SM Hollenberg, M Singer - Nature Reviews Cardiology, 2021 - nature.com
Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to
infection and is the leading cause of death in intensive care units. Cardiac dysfunction …

The SOFA score—development, utility and challenges of accurate assessment in clinical trials

S Lambden, PF Laterre, MM Levy, B Francois - Critical Care, 2019 - Springer
Abstract The Sequential Organ Failure Assessment or SOFA score was developed to assess
the acute morbidity of critical illness at a population level and has been widely validated as a …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Management of cardiogenic shock complicating myocardial infarction: an update 2019

H Thiele, EM Ohman, S de Waha-Thiele… - European heart …, 2019 - academic.oup.com
Cardiogenic shock (CS) remains the most common cause of death in patients admitted with
acute myocardial infarction (AMI) and mortality remained nearly unchanged in the range of …

The artificial intelligence clinician learns optimal treatment strategies for sepsis in intensive care

M Komorowski, LA Celi, O Badawi, AC Gordon… - Nature medicine, 2018 - nature.com
Sepsis is the third leading cause of death worldwide and the main cause of mortality in
hospitals,–, but the best treatment strategy remains uncertain. In particular, evidence …

Global epidemiology and outcomes of acute kidney injury

EAJ Hoste, JA Kellum, NM Selby, A Zarbock… - Nature Reviews …, 2018 - nature.com
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to decreased kidney function. In …

Sepsis and septic shock

M Cecconi, L Evans, M Levy, A Rhodes - The Lancet, 2018 - thelancet.com
Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Sepsis associated acute kidney injury

JT Poston, JL Koyner - Bmj, 2019 - bmj.com
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Landiolol and organ failure in patients with septic shock: the STRESS-L randomized clinical trial

T Whitehouse, A Hossain, GD Perkins, AC Gordon… - Jama, 2023 - jamanetwork.com
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse …

Sepsis-induced cardiomyopathy: a comprehensive review

M L'Heureux, M Sternberg, L Brath, J Turlington… - Current Cardiology …, 2020 - Springer
Abstract Purpose of Review To briefly review epidemiology and pathophysiology of SICM
and provide a more extensive review of the data on diagnostic and management strategies …