[HTML][HTML] Challenges and opportunities in modelling wet granulation in pharmaceutical industry–a critical review

M Singh, S Shirazian, V Ranade, GM Walker… - Powder Technology, 2022 - Elsevier
Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

Challenges and opportunities concerning numerical solutions for population balances: a critical review

M Singh, V Ranade, O Shardt… - Journal of Physics A …, 2022 - iopscience.iop.org
Population balance models are tools for the study of dispersed systems, such as granular
materials, polymers, colloids and aerosols. They are applied with increasing frequency …

Solution of population balance equations using the direct quadrature method of moments

DL Marchisio, RO Fox - Journal of Aerosol Science, 2005 - Elsevier
The implementation of a population balance equation (PBE) in computational fluid dynamics
(CFD) represents a crucial element in the simulation of multiphase flows. Some of the …

Perspectives on the current state, challenges, and opportunities in pharmaceutical crystallization process development

A Cote, D Erdemir, KP Girard, DA Green… - Crystal Growth & …, 2020 - ACS Publications
Crystallization is the primary process used to purify synthetic drug substances and
intermediates as well as to control bulk properties, including particle size, surface area, and …

Hybrid method of moments for modeling soot formation and growth

ME Mueller, G Blanquart, H Pitsch - Combustion and Flame, 2009 - Elsevier
In this work, a new statistical model for soot formation and growth is developed and
presented. The Hybrid Method of Moments (HMOM) seeks to combine the advantages of two …

Application of the direct quadrature method of moments to polydisperse gas–solid fluidized beds

R Fan, DL Marchisio, RO Fox - Powder technology, 2004 - Elsevier
Most of today's computational fluid dynamics (CFD) calculations for gas–solid flows are
carried out assuming that the solid phase is monodispersed, whereas it is well known that in …

Implementation of the quadrature method of moments in CFD codes for aggregation–breakage problems

DL Marchisio, RD Vigil, RO Fox - Chemical Engineering Science, 2003 - Elsevier
In this work the quadrature method of moments (QMOM) is implemented in a commercial
computational fluid dynamics (CFD) code (FLUENT) for modeling simultaneous aggregation …

Modelling of hydrate formation kinetics: State-of-the-art and future directions

CP Ribeiro Jr, PLC Lage - Chemical Engineering Science, 2008 - Elsevier
Clathrate hydrates have drawn considerable attention in the last few years due to a variety of
possible applications, including transportation and storage of natural gas and carbon …

Distribution characteristics of salt-out particles in steam turbine stage

P Hu, L Cao, J Su, Q Li, Y Li - Energy, 2020 - Elsevier
Exploring the distribution characteristics of salt-out particles on the blade surface is one of
the most urgent problems for supercritical steam turbine. To obtain more practical …

A quadrature-based moment method for dilute fluid-particle flows

O Desjardins, RO Fox, P Villedieu - Journal of Computational Physics, 2008 - Elsevier
Gas-particle and other dispersed-phase flows can be described by a kinetic equation
containing terms for spatial transport, acceleration, and particle processes (such as …