Richter transformation—is there light at the end of this tunnel?

TA Eyre - Hematology, 2023 - ashpublications.org
Richter transformation (RT) represents an uncommon (2% to 10%) but feared complication
of chronic lymphocytic leukemia (CLL). The disease is characterized by rapid disease …

Barriers to enrollment in clinical trials of patients with aggressive B-cell NHL that progressed after CAR T-cell therapy

ED Bezerra, M Iqbal, J Munoz, A Khurana… - Blood …, 2023 - ashpublications.org
Patients with relapsed/refractory (R/R) aggressive B-cell non-Hodgkin lymphoma (NHL) after
anti-CD19 chimeric antigen receptor T-cell therapy (CART19) have poor prognosis with a …

Challenges identifying DLBCL patients with poor outcomes to upfront chemoimmunotherapy and its impact on frontline clinical trials

SA Atallah-Yunes, A Khurana, M Maurer - Leukemia & Lymphoma, 2024 - Taylor & Francis
Diffuse large B cell lymphoma (DLBCL) has a variable course of disease among patients as
it consists of subgroups that are clinically, biologically and molecularly heterogeneous. In …

Evaluating the impact of laboratory-based eligibility criteria by race/ethnicity in first-line clinical trials of DLBCL

A Khurana, R Mwangi, LJ Nastoupil… - Blood …, 2024 - ashpublications.org
Underrepresentation of racial and ethnic subgroups in cancer clinical trials remains a
persistent challenge. Restrictive clinical trial eligibility criteria have been shown to …

A lack of diversity, equity, and inclusion in clinical research has direct impact on patient care

TC El-Galaly, VI Gaidzik, MA Gaman, D Antic… - …, 2023 - journals.lww.com
Diversity, equity, and inclusion (DEI) in research is important. This is the case not only
because it is simply the right thing to do but also because DEI fosters collaboration …

[PDF][PDF] Evaluating Lab-Based Eligibility Criteria by Race/Ethnicity in Clinical Trials of Diffuse Large B-Cell Lymphoma

A Khurana, R Mwangi, LJ Nastoupil, PM Reagan… - Blood Adv, 2024 - 61.8.75.226
Underrepresentation of racial and ethnic subgroups in cancer clinical trials remains a
persistent challenge. Restrictive clinical trial eligibility criteria have been shown to …

The impact of trial inclusion criteria on outcomes in DLBCL patients treated with R-CHOP in the first line: a Danish nationwide study

MR Simonsen, LM Haunstrup, FT Severinsen… - Leukemia & …, 2024 - Taylor & Francis
Up to 50% of diffuse large B-cell lymphoma (DLBCL) patients are ineligible for participation
in clinical trials. Ineligible patients have inferior outcomes, but less is known about the …

Challenges for quality and utilization of real-world data for diffuse large B-cell lymphoma in REALYSA, a LYSA cohort

H Ghesquières, F Cherblanc, A Belot, S Micon… - Blood …, 2024 - ashpublications.org
Real-world data (RWD) are essential to complement clinical trial (CT) data, but major
challenges remain, such as data quality. REal world dAta in LYmphoma and Survival in …

Impact of patient demographics and neighborhood socioeconomic variables on clinical trial participation patterns for NHL

C Nze, CR Andersen, AA Ayers, J Westin… - Blood …, 2024 - ashpublications.org
Prior studies have demonstrated that certain populations including older patients,
racial/ethnic minority groups, and women are underrepresented in clinical trials. We …

Improving eligibility criteria for first-line trials for patients with DLBCL using a US-based Delphi-method survey

RA Harkins, SP Patel, MJ Lee, JM Switchenko… - Blood …, 2022 - ashpublications.org
Recent first-line randomized controlled trials (RCTs) for patients with diffuse large B-cell
lymphoma (DLBCL) have shown negative results, which may be due in part to onerous …