Stability of lyophilized and spray dried vaccine formulations

KB Preston, TW Randolph - Advanced Drug Delivery Reviews, 2021 - Elsevier
Liquid formulations of vaccines are subject to instabilities that result from degradation
processes that proceed via a variety of physical and chemical pathways. In dried …

Adenoviral-vectored next-generation respiratory mucosal vaccines against COVID-19

S Afkhami, A Kang, V Jeyanathan, Z Xing… - Current Opinion in …, 2023 - Elsevier
The world is in need of next-generation COVID-19 vaccines. Although first-generation
injectable COVID-19 vaccines continue to be critical tools in controlling the current global …

[HTML][HTML] Stabilizing vaccines via drying: Quality by design considerations

Z Ghaemmaghamian, R Zarghami, G Walker… - Advanced Drug Delivery …, 2022 - Elsevier
Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …

Viral-vectored respiratory mucosal vaccine strategies

M Jeyanathan, S Afkhami, A Kang, Z Xing - Current Opinion in Immunology, 2023 - Elsevier
Increasing global concerns of pandemic respiratory viruses highlight the importance of
developing optimal vaccination strategies that encompass vaccine platform, delivery route …

Spray drying and particle engineering in dosage form design for global vaccines

M Gomez, R Vehring - Journal of Aerosol Medicine and Pulmonary …, 2022 - liebertpub.com
Vaccines are a very important tool in the effort to reduce the global burden of infectious
diseases. Modern vaccines can be formulated in several ways to induce specific immunity …

Clinical and Preclinical Methods of Heat-Stabilization of Human Vaccines

GL Williamson, EM Bachelder… - Molecular …, 2024 - ACS Publications
Vaccines have historically faced challenges regarding stability, especially in regions lacking
a robust cold chain infrastructure. This review delves into established and emergent …

[HTML][HTML] Dextran mass ratio controls particle drying dynamics in a thermally stable dry powder vaccine for pulmonary delivery

M Manser, BA Morgan, X Feng, RG Rhem… - Pharmaceutical …, 2022 - Springer
Purpose Thermally stable, spray dried vaccines targeting respiratory diseases are promising
candidates for pulmonary delivery, requiring careful excipient formulation to effectively …

Bioinformatic, Biochemical, and Immunological Mining of MHC Class I Restricted T Cell Epitopes for a Marburg Nucleoprotein Microparticle Vaccine

PE Harris, S Burkholz, CV Herst, RM Rubsamen - Vaccines, 2024 - mdpi.com
The Marburg virus (MARV), the virus responsible for Marburg hemorrhagic fever (MHF), is
considered a top-priority pathogen for vaccine development. Recent outbreaks in Equatorial …

Antimicrobial Peptides and Proteins for Inhalation

Y Wang, RYK Chang, WJ Britton, HK Chan - Respiratory Delivery of …, 2024 - Springer
Antimicrobial peptides and proteins (APPs) are gaining attraction as powerful agents against
multidrug-resistant bacteria. The inhalation delivery of APPs has emerged as a potent tool …

Intranasal and Inhaled Vaccines

MYT Chow, JKW Lam - Respiratory Delivery of Biologics, Nucleic Acids …, 2024 - Springer
Many respiratory infections have epidemic and pandemic potential, as evidenced by
influenza and the recent COVID-19 pandemic. Vaccination is an established and effective …