As an indispensable component of recombinant fusion proteins, linkers have shown
increasing importance in the construction of stable, bioactive fusion proteins. This review …

BACKGROUND: Traditional cancer therapy can be successful in destroying tumors, but can
also cause dangerous side effects. Therefore, many targeted therapies are in development …

Traditional anti-cancer treatments consist of chemotherapeutic drugs that effectively
eliminate rapidly dividing tumor cells. However, in many cases chemotherapy fails to …

RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Transferrin (Trf) is a highly conserved serum glycoprotein mostly known for its iron transport
capacity. As iron is an indispensable nutrient for cell division, Trf and its receptor have long …

Molecular farming in plants is an emerging platform for the production of pharmaceutical
proteins, and host species such as tobacco are now becoming competitive with …

Immunotoxins are chimeric molecules, which combine antibody specificity to recognize and
bind with high-affinity tumor-associated antigens (TAA) with the potency of the enzymatic …

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong
to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics …

The clinical development of immunotoxins in the treatment of solid tumors has been
impeded in part, by the induction of an immune response directed primarily against the toxin …

In this study, peptide entry inhibitors against the fusion processes of severe acute respiratory
syndrome coronavirus-2 (SCV2) and influenza A virus (IAV) were designed and evaluated …