Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

The entorhinal cortex (EC) is the major input and output structure of the hippocampal
formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes …

Human episodic memory critically depends on subregions of the medial temporal lobe,
which are part of functional brain systems such as the anterior-temporal and the posterior …

In recent years, the field has reached an impasse between models suggesting that the
hippocampus is fundamentally involved in spatial processing and models suggesting that …

The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction
may underlie episodic-memory decline in aging and dementia. Postmortem data indicate …

Physical exercise can convey a protective effect against cognitive decline in ageing and
Alzheimer's disease. While the long-term health-promoting and protective effects of exercise …

The hippocampus is proposed to be critical in distinguishing between similar experiences by
performing pattern separation computations that create orthogonalized representations for …

In this chapter, we review evidence that the cortical pathways to the hippocampus appear to
extend from two large-scale cortical systems: a posterior medial (PM) system that includes …

The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …

Searching for food, friends, and mates often begins with an airborne scent. Importantly, odor
concentration rises with physical proximity to an odorous source, suggesting a framework for …