Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …

VAN ROSSUM, DU-K. HANISCH AND R. QUIRION. Neuroanatomical localization,
pharmacological characterization and functions of CGRP, related peptides and their …

The role of gastrointestinal hormones in the regulation of appetite is reviewed. The
gastrointestinal tract is the largest endocrine organ in the body. Gut hormones function to …

Insulin and amylin are cosecreted by pancreatic B cells and have receptors within the
central nervous system (CNS), where they exert multiple effects. Although these peptides …

A. Peripherally acting agents B. Centrally acting agents IV. Drugs That Alter Metabolism A.
Preabsorptive agents B. Postabsorptive modifiers of nutrient metabolism V. Drugs That …

Peptide hormones released from the gastrointestinal tract communicate information about
the current state of energy balance to the brain. These hormones regulate appetite and …

The increasing prevalence of obesity worldwide has imparted renewed impetus to the study
of the mechanisms of appetite regulation. Digestion and nutrient absorption take place in the …

Amylin is a recently discovered 37 amino acid peptide which is co-secreted from the
pancreas with insulin and acts to modulate carbohydrate metabolism. Recently, high-affinity …

Food intake is a regulated system. Afferent signals provide information to the central nervous
system, which is the centre for the control of satiety or food seeking. Such signals can begin …

Adult male rats were intraperitoneally (IP) injected with 1.0 μg/kg amylin at the beginning of
the dark phase in 24 h food deprived or undeprived rats, and a computerized system …