Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

After undergoing metabolic reprogramming, tumor cells consume additional glutamine to
produce amino acids, nucleotides, fatty acids, and other substances to facilitate their …

Triple-negative breast cancer (TNBC) metabolism and cell growth uniquely rely on
glutamine uptake by the transporter ASCT2. Despite previous data reporting cell growth …

Purines are ancient metabolites with established and emerging metabolic and non-
metabolic signaling attributes. The expression of purine metabolism-related genes is …

Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has
substantial biological effects, underlining the need to better understand the function of GTP …

Hepatocellular carcinoma (HCC) is a malignant tumor characterized by rapid progression.
To explore the regulatory mechanism of rapid tumor growth and metastasis, we conducted …

Glutamine is a conditionally essential amino acid important for cancer cell proliferation
through intermediary metabolism leading to de novo synthesis of purine and pyrimidine …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide.
The in-depth study of genes and metabolites related to nucleotide metabolism will provide …

Viruses actively reprogram the metabolism of the host to ensure the availability of sufficient
building blocks for virus replication and spreading. However, relatively little is known about …

Simple Summary Prostate cancer (PC) is a hormone-dependent disease in which
metabolism deregulation has been identified as a relevant event. In particular, glutamine …