Tumor organoids inherit the genomic and molecular characteristics of the donor tumor,
which not only bridge the gap between genome and phenotype but also circumvent the …

Abstract Three-dimensional (3D) organoids are a novel tool to model epithelial cell biology
and human diseases of the esophagus. 3D organoid culture systems have been utilized to …

Allergic diseases are a global health challenge. Individuals harboring loss-of-function
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …

Although morphologic progression coupled with expression of specific molecular markers
has been characterized along the esophageal squamous differentiation gradient, the …

Background & Aims Although basal cell hyperplasia is a histologic hallmark of eosinophilic
esophagitis (EoE), little is known about the capabilities of epithelial renewal and …

During alcohol consumption, the esophageal mucosa is directly exposed to high
concentrations of ethanol (EtOH). We therefore investigated the response of normal human …

Organoids have been developed in the last decade as a new research tool to simulate
organ cell biology and disease. Compared to traditional 2D cell lines and animal models …

Self-renewing, damage–repair and differentiation of mammalian stratified squamous
epithelia are subject to tissue homeostasis, but the regulation mechanisms remain elusive …

Organoid culture systems are very powerful models that recapitulate in vivo organ
development and disease pathogenesis, offering great promise in basic research, drug …

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of
human malignancy, often displaying limited therapeutic response. Here, we examine the …