Challenges and future directions for studying effects of host genetics on the gut microbiome
The human gut microbiome is a complex ecosystem that is involved in its host's metabolism,
immunity and health. Although interindividual variations in gut microbial composition are …
immunity and health. Although interindividual variations in gut microbial composition are …
Genetics of type 2 diabetes—pitfalls and possibilities
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with …
WT Garvey, JI Mechanick, EM Brett, AJ Garber… - Endocrine Practice, 2016 - Elsevier
Objective Development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and the American College of …
Clinical Endocrinologists (AACE) Board of Directors and the American College of …
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
AK Manning, MF Hivert, RA Scott, JL Grimsby… - Nature …, 2012 - nature.com
Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …
Genomics, type 2 diabetes, and obesity
MI McCarthy - New England Journal of Medicine, 2010 - Mass Medical Soc
Genomics, Type 2 Diabetes, and Obesity | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Replicability and prediction: lessons and challenges from GWAS
Since the publication of the Wellcome Trust Case Control Consortium (WTCCC) landmark
study a decade ago, genome-wide association studies (GWAS) have led to the discovery of …
study a decade ago, genome-wide association studies (GWAS) have led to the discovery of …
Association between a literature-based genetic risk score and cardiovascular events in women
NP Paynter, DI Chasman, G Paré, JE Buring, NR Cook… - Jama, 2010 - jamanetwork.com
Context While multiple genetic markers associated with cardiovascular disease have been
identified by genome-wide association studies, their aggregate effect on risk beyond …
identified by genome-wide association studies, their aggregate effect on risk beyond …
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a
major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We …
major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We …
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC …
InterAct Consortium - Diabetologia, 2011 - Springer
Aims/hypothesis Studying gene–lifestyle interaction may help to identify lifestyle factors that
modify genetic susceptibility and uncover genetic loci exerting important subgroup effects …
modify genetic susceptibility and uncover genetic loci exerting important subgroup effects …
Genome-wide association study identifies three novel loci for type 2 diabetes
K Hara, H Fujita, TA Johnson… - Human molecular …, 2014 - academic.oup.com
Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a
large genetic component to be clarified. To explore unidentified loci for T2D, we performed a …
large genetic component to be clarified. To explore unidentified loci for T2D, we performed a …