The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

Sexual dimorphism in human immune systems is most apparent in the female
predominance of certain autoimmune diseases (ADs) like systemic lupus erythematosus …

Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem and potentially
life-threatening autoimmune disorder with significant associated morbidity. Evidence-based …

Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune
system and represent 2 sides of the same coin. Multiple single-gene defects have been …

The complement cascade is part of the innate immune system whose actions protect hosts
from pathogens. Recent research shows complement involvement in a wide spectrum of …

Objectives To report the phenotypic, genetic findings and outcome of children with lupus
manifestations associated with primary immunodeficiency diseases (PIDs). Methods Data …

Objective To report the differences in phenotypic characteristics, disease course, and
outcome in monogenic and sporadic childhood lupus (SC-lupus) from a single tertiary …

Background Human C1q deficiency is associated with systemic lupus erythematosus (SLE)
and increased susceptibility to severe bacterial infections. These patients require extensive …

Objective To report the clinical and genetic features of the first cases of chronic atypical
neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome …

Treatment and outcome of systemic lupus erythematosus (SLE) in C1q deficient patients are
rarely reported. The aim of this report is to share our experience about the course of …