The vast majority of total hip prostheses currently implanted consist of a hard metal or
ceramic femoral head articulating against an ultra-high molecular weight polyethylene …

Total hip arthroplasty is one of the most commonly performed and successful elective
orthopaedic procedures. However, numerous failure mechanisms limit the long-term …

Periprosthetic osteolysis—bone loss in the vicinity of a prosthesis—is the most serious
problem limiting the longevity of artificial joints. It is caused by bone-resorptive responses to …

The less intense tissue reaction around metal on metal total hip replacements (THRs)
compared to metal on polyethylene (PE) THRs may be explained by the differences in the …

We report a novel material that appears to stimulate cytokine production in human
osteoblasts and allow good adherence of the cells to the material. We have examined …

Since the recognition of aseptic loosening by Charnley in the early 1960s, much information
has been gained on the basic science of periprosthetic bone loss. Initially termed cement …

Most cast dental restorations are made from alloys or commercially pure titanium (cpTi).
Many orthodontic appliances are also fabricated from metallic materials. It has been …

Particulate wear‐debris are detected in histiocytes/macrophages of granulomatous tissues
adjacent to loose joint prostheses. Such cell‐particle interactions have been simulated in …

Migration of solid corrosion products from the modular head-neck junction of fifteen total hip
replacements to the periprosthetic tissues was studied. The devices and tissues were …

Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip
replacements were examined. Particles in the membranes were characterised by electron …