Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

This paper discusses the current evidence from animal and human studies for a central role
of inflammation in schizophrenia. In animal models, pre-or perinatal elicitation of the immune …

BackgroundConverging lines of evidence implicate an important role for the immune system
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …

Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut
microbiota can signal to the brain via the immune system, the vagus nerve or other host …

Abstract The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging
biomarker of brain injury and neuroinflammation has increased exponentially in the last …

Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence
of a complex and dynamic bidirectional interaction of genetic expression and the …

Objective Schizophrenia poses a tremendous health, social, and economic burden upon
patients and society, indicating current treatment options remain inadequate. Recent …

A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

Schizophrenia is a psychiatric disorder with significant impact on individuals and society.
The current pharmacologic treatment, which principally alleviates psychosis, is focused on …

Psychotic disorders are common and disabling. Overlaps in clinical course in addition to
epidemiological and genetic associations raise the possibility that autoimmune mechanisms …