Sleep has a critical role in promoting health. Research over the past decade has
documented that sleep disturbance has a powerful influence on the risk of infectious …

Sleep and its impact on health has been increasingly explored over the past few decades.
Sleep loss has negative impacts on quality of life, mood, cognitive function, and health …

Epidemiological studies indicate that stress, chronic depression and lack of social support
might serve as risk factors for cancer development and progression. Recent cellular and …

Background: Abnormal circadian rhythms have been observed in patients with cancer, but
the prognostic value of such alterations has not been confirmed. We examined the …

Cancer-related fatigue (CRF) is one of the most prevalent symptoms patients with cancer
experience, both during and after treatment. CRF is pervasive and affects patients' quality of …

With many real-world examples, this book shows how to apply the powerful methods of
smoothing splines in practice. It covers basic smoothing spline models as well as more …

BACKGROUND. The question of whether stress poses a risk for cancer progression has
been difficult to answer. A randomized clinical trial tested the hypothesis that cancer patients …

Various features, components, and functions of the immune system present daily variations.
Immunocompetent cell counts and cytokine levels present variations according to the time of …

Pronounced circadian rhythms in numbers of circulating T cells reflect a systemic control of
adaptive immunity whose mechanisms are obscure. Here, we show that circadian variations …

Context: Cortisol has a distinct circadian rhythm regulated by the brain's central pacemaker.
Loss of this rhythm is associated with metabolic abnormalities, fatigue, and poor quality of …