New drug delivery systems developed for brain targeting
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …
the most complex and sophisticated concierges that defend the central nervous system …
Hyaluronic acid scaffolds for loco-regional therapy in nervous system related disorders
A Djoudi, R Molina-Peña, N Ferreira, I Ottonelli… - International Journal of …, 2022 - mdpi.com
Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-
acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its …
acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its …
[HTML][HTML] Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement
NA Abdulla, GF Balata, HA El-Ghamry… - Saudi Pharmaceutical …, 2021 - Elsevier
Limited solubility and hepatic first-pass metabolism are the main causes of low
bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to …
bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to …
[HTML][HTML] Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity …
Nano-structured lipid carriers containing zopiclone were prepared as a targeted drug
delivery system to convey zopiclone directly to brain via nasal route. Nano-structured lipid …
delivery system to convey zopiclone directly to brain via nasal route. Nano-structured lipid …
Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity
This study aimed to formulate diacerein loaded terpene-enriched invasomes (DCN-TINV) to
fulfill a fruitful management of osteoarthritis. A 23 factorial design was adopted, including A …
fulfill a fruitful management of osteoarthritis. A 23 factorial design was adopted, including A …
Microemulsions as lipid nanosystems loaded into thermoresponsive in situ microgels for local ocular delivery of prednisolone
This study aimed to develop and evaluate thermoresponsive in situ microgels for the local
ocular delivery of prednisolone (PRD)(PRD microgels) to improve drug bioavailability and …
ocular delivery of prednisolone (PRD)(PRD microgels) to improve drug bioavailability and …
Self-assembling lecithin-based mixed polymeric micelles for nose to brain delivery of clozapine: In-vivo assessment of drug efficacy via radiobiological evaluation
FM Elsharkawy, MM Amin… - International Journal …, 2023 - Taylor & Francis
Purpose The research objective is to design intranasal brain targeted CLZ loaded lecithin
based polymeric micelles (CLZ-LbPM) aiming to improve central systemic CLZ …
based polymeric micelles (CLZ-LbPM) aiming to improve central systemic CLZ …
Sonophoresis-assisted transdermal delivery of antimigraine-loaded nanolipomers: Radio-tracking, histopathological assessment and in-vivo biodistribution study
Migraine is a disabling neurovascular polygenic disorder affecting life quality with escorted
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …
Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by 99mTc radiolabeling technique
Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …
Fabricating polymer/surfactant/cyclodextrin hybrid particles for possible nose-to-brain delivery of ropinirole hydrochloride: In vitro and ex vivo evaluation
Ropinirole is a non-ergolinic dopamine agonist used to manage Parkinson's disease and it
is characterized by poor oral bioavailability. This study aimed to design and develop …
is characterized by poor oral bioavailability. This study aimed to design and develop …