Novel delivery systems for improving the clinical use of peptides

M Kovalainen, J Mönkäre, J Riikonen, U Pesonen… - Pharmacological …, 2015 - Elsevier
Peptides have long been recognized as a promising group of therapeutic substances to treat
various diseases. Delivery systems for peptides have been under development since the …

Research progress of physical transdermal enhancement techniques in tumor therapy

W Han, F Liu, G Liu, H Li, Y Xu, S Sun - Chemical Communications, 2023 - pubs.rsc.org
The advancement and popularity of transdermal drug delivery (TDD) based on the physical
transdermal enhancement technique (PTET) has opened a new paradigm for local tumor …

Investigation of ethyl cellulose microsponge gel for topical delivery of eberconazole nitrate for fungal therapy

C Bothiraja, AD Gholap, KS Shaikh… - Therapeutic …, 2014 - Taylor & Francis
Background: The aim of the study was to investigate ethyl cellulose microsponges as topical
carriers for the controlled release and cutaneous drug deposition of eberconazole nitrate …

Topical and transdermal delivery with diseased human skin: Passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin

B Dasht Bozorg, SA Bhattaccharjee… - Drug delivery and …, 2022 - Springer
Psoriasis and atopic dermatitis (eczema) are both common immune-mediated inflammatory
skin diseases associated with changes in skin's stratum corneum lipid structure and barrier …

Transdermal delivery of breakthrough therapeutics for the management of treatment-resistant and post-partum depression

SA Bhattaccharjee, KS Murnane, AK Banga - International journal of …, 2020 - Elsevier
For the first time in over three decades, the year 2019 saw the approval of two new classes
of antidepressants: Spravato™ esketamine intranasal spray for treatment-resistant …

Formulation and evaluation of microsponge gel for topical delivery of fluconazole for fungal therapy

N Patel, N Padia, N Vadgama, M Raval… - Journal of Pharmaceutical …, 2016 - Springer
The aim of the present research was to develop Fluconazole loaded microsponge-based
topical delivery system for controlled release and enhanced drug deposition in the skin …

Numerical simulation of iontophoresis for in-silico prediction of transdermal drugs in the dermal layers using skin impedance values

DJ Bora, R Dasgupta - Computer Methods and Programs in Biomedicine, 2022 - Elsevier
Background and objective: Transdermal delivery of a therapeutic drug is a non-invasive
method of drug administration. For a controlled delivery of the maximum number of drugs …

Comparison of liposomal drug formulations for transdermal iontophoretic drug delivery

K Malinovskaja-Gomez, S Espuelas, MJ Garrido… - European Journal of …, 2017 - Elsevier
This study was aimed to evaluate the in vitro transdermal direct/pulsed current iontophoretic
delivery of an amphiphilic model compound from various lipid vesicle-encapsulated …

Effect of lipophilicity on microneedle-mediated iontophoretic transdermal delivery across human skin in vitro

KR Pawar, F Smith, CS Kolli, RJ Babu - Journal of Pharmaceutical Sciences, 2013 - Elsevier
The effect of lipophilicity of drug on the microneedle (MN)-mediated iontophoretic delivery
across dermatomed human skin was studied. Beta blockers with similar p K a but varied log …

Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin

AP Raphael, CA Primiero, AB Ansaldo… - Journal of controlled …, 2013 - Elsevier
The delivery of therapeutics and cosmaceuticals into and/or through the skin is hindered by
epidermal barriers. To overcome the skin's barriers we have developed a novel cutaneous …