Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign
RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations …

Liver ischemia reperfusion activates innate immune system to drive the full development of
inflammatory hepatocellular injury. Damage-associated molecular patterns (DAMPs) …

Damage-associated molecular patterns are signalling molecules involved in inflammatory
responses and restoration of homeostasis. Chronic release of these molecules can also …

Numerous human diseases arise from alterations of genetic information, most notably DNA
mutations. Thought to be merely the intermediate between DNA and protein, changes in …

Inflammation is a natural response of the body to signals of tissue damage or infection
caused by pathogens. However, when it becomes imbalanced, it can lead to various …

HBV is considered as a “stealth” virus that does not invoke interferon (IFN) responses;
however, the mechanisms by which HBV bypasses innate immune recognition are poorly …

The nuclear receptors farnesoid X receptor (FXR; NR1H4) and small heterodimer partner
(SHP; NR0B2) play crucial roles in bile acid homeostasis. Global double knockout of FXR …

Background: Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA)
development. However, molecular mechanisms controlling macrophage activation and …

Astrocytes affect stroke outcomes by acquiring functionally dominant phenotypes.
Understanding molecular mechanisms dictating astrocyte functional status after brain …

Abstract Background Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset
autoimmune disease characterized by inflammatory encephalopathy with an elevated type 1 …