In this review, we focus on the biophysics of cell membrane lipids, particularly when cancers
develop acquired drug resistance, and how biophysical changes in resistant cell membrane …

Bcl-2-family proteins are central regulators of cell life and death. At least three major classes
of Bcl-2-family proteins have been delineated, including proapoptotic proteins that contain …

One of the most effective ways to combat different types of cancer is through early diagnosis
and administration of effective treatment, followed by efficient monitoring that will allow …

Mitochondria play a central role in cell life and death and are known to be important in a
wide range of diseases including the cancer, diabetes, cardiovascular disease, and the age …

The mitochondrion is the most important organelle in determining continued cell survival
and cell death. Mitochondrial dysfunction leads to many human maladies, including …

Mitochondria, the cells powerhouses, are essential for maintaining cell life, and they also
play a major role in regulating cell death, which occurs upon permeabilization of their …

The IκB kinase complex (IKK) is a key regulator of immune responses, inflammation, cell
survival, and tumorigenesis. The prosurvival function of IKK centers on activation of the …

Although hsp70 antagonizes apoptosis-inducing factor (AIF)-mediated cell death, the
relative importance of preventing its release from mitochondria versus sequestering leaked …

The molecular mechanisms governing severe acute respiratory syndrome coronavirus-
induced pathology are not fully understood. Virus infection and some individual viral …

The purpose of this phase I study was to determine the potential efficacy of adenoviral-
mediated suicide gene therapy in women with recurrent ovarian cancer. Fourteen patients …