Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

Y Zhou, A Shao, Y Yao, S Tu, Y Deng… - Cell Communication and …, 2020 - Springer
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …

Immune regulation in the aging retina

M Chen, C Luo, J Zhao, G Devarajan, H Xu - Progress in retinal and eye …, 2019 - Elsevier
The retina is an immune privileged tissue, which is protected from external and internal
insults by its blood-retina barriers and immune suppressive microenvironment. Apart from …

Revisiting excitotoxicity in traumatic brain injury: from bench to bedside

D Baracaldo-Santamaría, DF Ariza-Salamanca… - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …

Glutamate neurotransmission in rodent models of traumatic brain injury

CR Dorsett, JL McGuire, EAK DePasquale… - Journal of …, 2017 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of death and disability in people younger than
45 and is a significant public health concern. In addition to primary mechanical damage to …

Traumatic brain injury: a risk factor for neurodegenerative diseases

R Gupta, N Sen - Reviews in the Neurosciences, 2016 - degruyter.com
Traumatic brain injury (TBI), a major global health and socioeconomic problem, is now
established as a chronic disease process with a broad spectrum of pathophysiological …

Neuroinflammation in post-traumatic epilepsy: pathophysiology and tractable therapeutic targets

R Sharma, WL Leung, A Zamani, TJ O'brien… - Brain sciences, 2019 - mdpi.com
Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …

[HTML][HTML] Aging and injury: alterations in cellular energetics and organ function

N Poulose, R Raju - Aging and disease, 2014 - ncbi.nlm.nih.gov
Aging is characterized by increased oxidative stress, heightened inflammatory response,
accelerated cellular senescence and progressive organ dysfunction. The homeostatic …

Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology

C Muñoz‐Ballester, S Robel - WIREs Mechanisms of Disease, 2023 - Wiley Online Library
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make‐up
and cell biology, which results in changes in astrocyte function. These changes can be …

Neuron‐restrictive silencer factor/repressor element 1‐silencing transcription factor (NRSF/REST) controls spatial K+ buffering in primary cortical astrocytes

E Centonze, A Marte, M Albini, A Rocchi… - Journal of …, 2023 - Wiley Online Library
Neuron‐restrictive silencer factor/repressor element 1 (RE1)‐silencing transcription factor
(NRSF/REST) is a transcriptional repressor of a large cluster of neural genes containing …