Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Immunotherapy exerts its excellent anti-tumor effects by stimulating and enhancing the
immune response of the body, and has become another important class of anti-tumor …

Immunotherapy has revolutionized the treatment of dozens of cancers and became a
standard of care for some tumor types. However, the majority of patients do not benefit from …

A higher density of tumor infiltrating lymphocytes (TILs) in the tumor microenvironment,
particularly cytotoxic CD8+ T cells, is associated with improved clinical outcome in various …

Immunotherapies with immune checkpoint inhibitors or adoptive cell transfer have become
powerful tools to treat cancer. These treatments act via overcoming or alleviating tumor …

Cancer remains a significant global health challenge with limited treatment options beyond
systemic therapies, such as chemotherapy, radiotherapy, and molecular targeted therapy …

Cancer biomechanical properties, including high stiffness, solid stress, and interstitial
pressure, as well as altered micro-architecture, are drivers of tumorigenesis, invasiveness …

Purpose: To explore the cellular cross-talk of tumor-resident mast cells (MC) in controlling
the activity of cancer-associated fibroblasts (CAF) to overcome tumor microenvironment …

Background T-cell immunoreceptor with Ig and ITIM domains (TIGIT) participates in tumor
immune escape by delivering inhibitory signals to T cells. The purpose of this article was to …

Currently, researchers have increasingly focused on 3D in vitro tumor models as they
possess the capacity to replicate tissue-like characteristics and cell-cell interactions within …