Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
Integrating experimental data with molecular simulations to investigate RNA structural dynamics
M Bernetti, G Bussi - Current Opinion in Structural Biology, 2023 - Elsevier
Conformational dynamics is crucial for ribonucleic acid (RNA) function. Techniques such as
nuclear magnetic resonance, cryo-electron microscopy, small-and wide-angle X-ray …
nuclear magnetic resonance, cryo-electron microscopy, small-and wide-angle X-ray …
Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway
T Uroda, E Anastasakou, A Rossi, JM Teulon… - Molecular cell, 2019 - cell.com
Long non-coding RNAs (lncRNAs) are key regulatory molecules, but unlike with other RNAs,
the direct link between their tertiary structure motifs and their function has proven elusive …
the direct link between their tertiary structure motifs and their function has proven elusive …
Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble
T-box riboswitches are multi-domain noncoding RNAs that surveil individual amino acid
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …
Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery
In recent years, researchers have identified certain RNAs as druggable targets for small
molecules to treat several human pathologies. However, these regulatory RNAs are …
molecules to treat several human pathologies. However, these regulatory RNAs are …
Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly
High-resolution structural studies are essential for understanding the folding and function of
diverse RNAs. Herein, we present a nanoarchitectural engineering strategy for efficient …
diverse RNAs. Herein, we present a nanoarchitectural engineering strategy for efficient …
Atomistic structure of the SARS-CoV-2 pseudoknot in solution from SAXS-driven molecular dynamics
W He, J San Emeterio, MT Woodside… - Nucleic acids …, 2023 - academic.oup.com
Abstract SARS-CoV-2 depends on− 1 programmed ribosomal frameshifting (− 1 PRF) to
express proteins essential for its replication. The RNA pseudoknot stimulating− 1 PRF is …
express proteins essential for its replication. The RNA pseudoknot stimulating− 1 PRF is …
On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules
RNA molecules play a vital role in biological processes within the cell, with significant
implications for science and medicine. Notably, the biological functions exerted by specific …
implications for science and medicine. Notably, the biological functions exerted by specific …
Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution
Long non-coding RNAs (lncRNAs) constitute a significant fraction of the transcriptome,
playing important roles in development and disease. However, our understanding of …
playing important roles in development and disease. However, our understanding of …
A guide to large-scale RNA sample preparation
RNA is becoming more important as an increasing number of functions, both regulatory and
enzymatic, are being discovered on a daily basis. As the RNA boom has just begun, most …
enzymatic, are being discovered on a daily basis. As the RNA boom has just begun, most …