PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche

H Liu, L Liu, CJ Rosen - Cells, 2024 - mdpi.com
Parathyroid hormone (PTH) plays a pivotal role in maintaining calcium homeostasis, largely
by modulating bone remodeling processes. Its effects on bone are notably dependent on the …

Expression and role of ubiquitin-specific peptidases in osteoblasts

H Hariri, R St-Arnaud - International Journal of Molecular Sciences, 2021 - mdpi.com
The ubiquitin-proteasome system regulates biological processes in normal and diseased
states. Recent investigations have focused on ubiquitin-dependent modifications and their …

Transcriptome analysis reveals modulation of human stem cells from the apical papilla by species associated with dental root canal infection

Y Razghonova, V Zymovets, P Wadelius… - International Journal of …, 2022 - mdpi.com
Interaction of oral bacteria with stem cells from the apical papilla (SCAP) can negatively
affect the success of regenerative endodontic treatment (RET). Through RNA-seq …

Ubiquitin specific peptidase Usp53 regulates osteoblast versus adipocyte lineage commitment

H Hariri, WN Addison, R St-Arnaud - Scientific reports, 2021 - nature.com
We have previously shown that parathyroid hormone (PTH) induces the phosphorylation of
the DNA-binding protein Nascent polypeptide associated complex And Coregulator alpha …

USP53 regulates bone homeostasis by controlling rankl expression in osteoblasts and bone marrow adipocytes

H Hariri, O Kose, A Bezdjian, SJ Daniel… - Journal of Bone and …, 2020 - academic.oup.com
In the skeleton, osteoblasts and osteoclasts synchronize their activities to maintain bone
homeostasis and integrity. Investigating the molecular mechanisms governing bone …

[HTML][HTML] Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

J Stevens, E Culberson, J Kinder, A Ramiriqui, J Gray… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The immunological defects causing susceptibility to severe viral respiratory infections due to
early-life dysbiosis remain ill-defined. Here, we show that influenza virus susceptibility in …

NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH

R St-Arnaud, M Pellicelli, M Ismail, A Arabian… - International Journal of …, 2022 - mdpi.com
PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through
Gαs and PKA. This leads to nuclear translocation of NACA and expression of the target gene …

[PDF][PDF] 白细胞介素3 在骨代谢中的作用及机制

王景, 熊山, 曹金, 冯林伟, 王信 - 中国组织工程研究, 2022 - cjter.com
白细胞介素3 在骨代谢中的作用及机制 Page 1 1260|中国组织工程研究|第26卷|第8期|2022年3月
中国组织工程研究 Chinese Journal of Tissue Engineering Research www.CJTER.com …

[图书][B] Structure Function Analysis of the NACA Coregulator Interaction with JNK Kinase in Osteoblasts

A Sahai - 2021 - search.proquest.com
Abstract The Mitogen Activated Protein Kinase (MAPK) pathway has been shown to be
involved in bone development. Osteoblast-specific Jnk1-/-mice present severe osteopenia …

[引用][C] Histopathogenesis of bone-and soft-tissue tumor spectrum with USP6 gene rearrangement: multiple partners involved in the tissue repair process.

M Legrand, ML Jourdan, G Pinieux - 2023 - Universidad de Murcia …