Mucins are the gatekeepers of the mucosal barrier of the gastrointestinal tract and are
aberrantly expressed in various gastrointestinal pathologies, including pathogen infection …

Aptamers (Apts) are synthetic nucleic acid ligands that can be engineered to target various
molecules, including amino acids, proteins, and pharmaceuticals. Through a series of …

Colorectal cancer (CRC) is a heterogeneous disease that commonly affects individuals
aged more than 50 years old globally. Regular colorectal screening, which is recommended …

Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

The polybromo-associated PBAF (SWI/SNF) chromatin remodeling complex, which includes
PBRM1, ARID2, and BRD7, regulates cell differentiation and genomic integrity. MUC1-C is …

Chronic inflammation is a highly prevalent consequence of changes in environmental and
lifestyle factors that contribute to the development of cancer. The basis for this critical …

Abstract The Brg/Brahma-associated factor (BAF, mSWI/SNF) chromatin remodeling
complex is of importance in development and has been linked to prostate oncogenesis. The …

Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can
promote cancer. Oncoprotein mucin 1 (MUC1) targets mitochondria to attenuate drug …

Simple Summary The evidence reviewed here indicates that MUC1-C evolved in mammals
to promote inflammatory adaptation in barrier tissues that extends to resident stem cells and …

Chronic inflammation promotes epigenetic reprogramming in cancer progression by
pathways that remain unclear. The oncogenic MUC1-C protein is activated by the …