Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Peptides and small proteins exhibiting antimicrobial activity have been isolated from many
organisms ranging from insects to humans, including plants. Their role in defense is …

Directed evolution is being used increasingly in industrial and academic laboratories to
modify and improve commercially important enzymes. Laboratory evolution is thought to …

Intercellular adhesion molecules (ICAMs) belong to the immunoglobulin superfamily and
participate in diverse cellular processes including host–pathogen interactions. ICAM-1 is …

Introduction Malaria and tuberculosis are highly infectious diseases declared a global health
emergency by the World Health Organization, and together they account for more than 1.5 …

Antimicrobial peptides (AMPs) are effector molecules of innate immune systems found in
different groups of organisms, including microorganisms, plants, insects, amphibians and …

Invasion of human erythrocytes by Plasmodium falciparum merozoites involves multiple
interactions between host receptors and their merozoite ligands. Here we report human …

Background Protein-protein interactions play a crucial role in enabling a pathogen to survive
within a host. In many cases the interactions involve a complex of proteins rather than just …

The spread of multidrug-resistant Gram-negative bacteria is an increasing threat to human
health, because novel compound classes for the development of antibiotics have not been …

Background The secretory proteins of Mycobacterium tuberculosis (M. tuberculosis) have
been known to be involved in the virulence, pathogenesis as well as proliferation of the …